Age prediction using ADN methylation

Resumen

Chronologicasl age estimation is a fundamental part for forensic science; it is used to establish a narrower profile for the search of suspects or for the identification of a corpse. In several articles based on the study of the genome it has been reported that ADN methylation promises to be a high precision marker for chronological age estimation. In the present study, articles that designed experimental models of age prediction were analyzed, including methylation patterns of characteristic genes related to the aging. In spite of the few analyzes that have focused on ADN methylation to determine age, in the great majority of them favorable results were obtained with a multivariate regression statistic; some of the hundreds of CpG sites were studied; although a greater number of CpG sites can provide greater accuracy than fewer CpG sites, such an approach can not be applied since the samples commonly found at the crime scene are usually limited.

Keywords: ADN, Forensics, Methilation, Age, Saliva, HumanMethylation450.