Age prediction using ADN methylation

Ana Sandoval-Rivera, Teresa de Jesús Lagunes-Torres, Carolina Barrientos-Salcedo

Resumen


Chronologicasl age estimation is a fundamental part for forensic science; it is used to establish a narrower profile for the search of suspects or for the identification of a corpse. In several articles based on the study of the genome it has been reported that ADN methylation promises to be a high precision marker for chronological age estimation. In the present study, articles that designed experimental models of age prediction were analyzed, including methylation patterns of characteristic genes related to the aging. In spite of the few analyzes that have focused on ADN methylation to determine age, in the great majority of them favorable results were obtained with a multivariate regression statistic; some of the hundreds of CpG sites were studied; although a greater number of CpG sites can provide greater accuracy than fewer CpG sites, such an approach can not be applied since the samples commonly found at the crime scene are usually limited.

Keywords: ADN, Forensics, Methilation, Age, Saliva, HumanMethylation450.



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DOI: https://doi.org/10.25009/revmedforense.v4i1.2610

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REVISTA MEXICANA DE MEDICINA FORENSE Y CIENCIAS DE LA SALUD, Revista de Divulgación del INSTITUTO DE MEDICINA FORENSE de la UNIVERSIDAD VERACRUZANA.

Año 1, No. 1, Febrero- Julio 2016, es una Publicación semestral editada por el INSTITUTO DE MEDICINA FORENSE de la UNIVERSIDAD VERACRUZANA, Av. S.S. Juan Pablo II, Esq. Jesús Reyes Heroles S/N, Fraccionamiento Costa Verde, C.P. 94294, Boca del Río, Veracruz. México. Tel (229)7 75 2000 Ext. 22011, 22501, 22503, www.uv.mx/veracruz/imf . Reserva de Derechos al Uso Exclusivo No. 04-2015-120316322300-203, ISSN 2448-8011 , ambos otorgados por el Instituto Nacional de Derecho de Autor. INSTITUTO DE MEDICINA FORENSE, 29 de Abril de 2016.

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